Thyroid dysgenesis presents in three major forms: thyroid ectopy, athyreosis and thyroid hypoplasia. Thyroid ectopy refers to an ectopic location of the thyroid gland. This accounts for two-thirds of congenital hypothyroidism due to thyroid dysgenesis and is twice as common in females [28]. In these cases, a thyroid remnant is usually found along the normal pathway of the thyroglossal duct. This represents the path taken by the developing thyroid as it descends from the base of the tongue to its final location in the neck [28, 29]. In one study done on hypothyroid neonates, ectopic thyroid tissue was found inferior and superior to the hyoid bone, and above the thyroid cartilage [30]. Athyreosis refers to the complete absence of thyroid tissue. Athyreosis and thyroid hypoplasia account for the remaining one third of thyroid dysgenesis.
The advent of newborn screening programs in the mid-1970s allowed earlier detection and treatment of infants with congenital hypothyroidism. Such efforts have been successful in achieving a much-improved neurocognitive outcome. Despite this, however, not all studies report a completely normal outcome. In a recent review of 51 published reports of IQ outcome in infants with congenital hypothyroidism as compared to sibling or classmate control subjects, 18 found no significant IQ difference, while 33 found a significant difference, with IQ ranging between 5 and 25 points lower in infants with congenital hypothyroidism [80]. In evaluating important variables, there is evidence that age of onset of treatment, starting l-thyroxine treatment dose, and severity of hypothyroidism each plays an important role in neurocognitive outcome.
Lazarus the complete guide.rar
It is a record of the battle of modern video creators that can be read by everyone who loves and enjoys movies, not just fans of ancient and modern Godzilla.Between the outer box and the main body is the "completed script" in the appendix! All the same content as the main part of the movie is recorded, including the dialogue, writing, and telop! Of course, the cast table with the title and title is included.
Witcher 3 has an outstanding modding stage, which can allow you not just actually remaster the game in every aspect, but bring many new content and features, and tailor the game up to your likings completely - which many Witcher series fans, surprisingly, are not aware about. I'm a diehard Witcher universe fan - started from reading the books back in my teenage years, and then playing every Witcher game upon its release, with Witcher 3 being one of favourite games in lifetime, drowning me for hundreds ofgameplay hours. One day, I've also discovered TW3 modding stage not just exists, but it's quite active and has plenty of absolutely amazing mods - this stunned me positively, and lead to yet new hundreds of hours spent in already modded TW3 walkthroughs. At the same time, TW3 modding can be quite clunky and confusing for a newcomer, and amount of mods is quite impressive - so picking between them, learning about compatibility aspects and some other moments may be really overwhelming to anyone who wants to dive into a modded walkthrough. That's why, I decided to collect and systemise all my experience and knowledge about this process, and share it with you folks - so you don't need to go through weeks of exhausting process yourself, no need to struggle with figuring out load order and being confused by script compilation errors. This guide is an easy-to-follow roadmap into TW3 modding. Following it, you will be able to build your own ultimate modded Witcher 3 experience - with best results possible and minimum efforts. That's it!
This project is completely free. Still, it takes insane amount of my time to build and expand it - the modding guides and other related modding content already took me over 6200 working hours in total. The more independent I will fee myself as an author - the less stress and more free time I'll have - and so, the faster new updates and modules will arrive, and new projects will appear as well. But support only if you really want it and able to:
A: Not such NASA PC as you may think! CPU - Intel i5 6600k (or AMD analogue), GTX 1080/2070/1660Ti (or AMD analogues), 16GB RAM - with similar specs you'll be be able to run a setup with all retextures, all needed lighting/weather/immersion mods, at max possible settings, with any Reshade preset you want, better shadows and LODs and so on. Yes, this guide is made for ALL rigs - no matter if your PC srong, not that much or a complete potato - you can find recommendations, and build best modded game possible.
6) Your game is GOG Goty, but it's 4.0/"next gen" (named "complete edition" in the library) and/or not in English? Open GOG Galaxy client and go to your Witcher 3 GOTY pane. Click on settings button (icon with two short lines with dots on top) ==> Manage Installation ==> Configure ==> Unckeck autoupdates and choose the 1.32 game version. Also make sure to select English language. Press OK. This now may take some time as Galaxy will need to re-download some files. Good! Now proceed straight to step 10 (skipping steps 7 to 9). Also take into account that after step 10, you don't need to implement step 11 for GOG game version - skip it and proceed to step 12.
8) You own Witcher 3 in Steam, and it's GOTY version (not a complete version, already installed)? Once again - if a few extra bucks spent to support CDPR is not a problem for you - get GOTY version at GOG. But if you don't want - it's possible to manage without it, using 2 extra steps below (step #10 and #11).
9) You own Witcher 3 in Steam, and it's "next gen" update (named "complete edition" in the library - either already installed, or you own the game and plan to install it)? Open "Betas" in the game management options in Steam, and choose version 1.32, as shown here. Install this version, not the complete version.
12) Install Mod Limit Adjuster. Witcher 3 is very "capricious" when it comes to mods amount. There's not scrict limit (like 255 plugin in Skyrim, for example), but game can go nuts with basically any mods amount, even just a few - this includes longer loading screens (or complete stucks on them), freezes, crashes, and just wide amount of most weird glitches. In past, it was very tedious to bypass this, as all you could do was to merge mods yourself, which also often leaded to new issues. No more! Mod Limit Adjuster is an engine fix which allows you to use as many mods as you want, simple as that. First of all, install Ultimate ASI Loader (it's required for Adjuster to work). Download the latest version x64 archive (namely the "Ultimate-ASI-Loader_x64.zip" file, release version 4.59 atm). Unpack it. Place the dinput8.dll file inside your Witcher 3 x64 folder (basically, where the witcher3.exe file is located). Make sure you downloaded exactly the 64 bit version of the loader - otherwise, Mod Limit Adjuster won't work correctly. Note: if you're 100% sure you have downloaded the correct file and installed it properly, but your game still crashes at launch (and only in this case), try to rename the file to d3d11.dll - it's a rarely happening issue to some users, and this solution helps with it. Now download the Mod Limit Adjuster archive. Unpack it. Place both "ModLimitAdjuster.asi" and "ModLimitAdjuster.cfg" inside your Witcher 3 x64 folder (same where you placed the previous file). Well done - you can now use as many mods as you want - feel the power!
A: Similar to ENB (it's like a less powerful younger brother of ENB), Reshade it's an external tool which adds visual shaders to the game which didn't exist in it to begin with, or similar ones, but with much better configuration potential. It works as an overlay and improves various graphics aspects of the game which are not directly related to models and textures, such as lighting, shadows, depth of field, and many other visual effects. Reshade itself is a pack of such shaders, while Reshade preset is a configuration file for them, and often some of those shaders tweaked by the preset author. A well made Reshade preset will make your game look much better, as just graphics mods themselves are not able to achieve that alone. Also, as it's highly customisable, it can allow to tailor the game look exactly up to your personal taste, which is basically its greatest feat. So, all you need is to browse the list of Reshade presets in this section, choose one you personally like the most, and install it. While you can find some of my personal recommendations about presets choice, in the end, it's completely subjective and totally up to you :)
A: Similar to step above, just delete existing preset files. If current and new presets are using different Reshade versions, then remove Reshade files completely, then install Reshade version needed for new preset, and then preset itself.
A: Those are also Reshade effects, called letterbox, depth of field and grain, respectively. They are completely optional and can be disabled in GUI anytime, or reenabled back. You control the Reshade, Reshade doesn't control you :)
Animations is a double-edged sword for Witcher 3. At one hand, vanilla animations themselves in the game are really well-made compared to most of other RPGs. At the same time, there's no limit to perfection - you may want to polish them, adjust to your liking, add animations for some actions that were lacking them, etc. Yet, when it comes to modding animations in this game, it's really hard to achieve that without glitches. Thus, there won't be lots of mods in this section - only those which are completely bug-free, or can have some minor bugs, but are too good in general so joy of using them is much higher than minor disadvantages.
zpaq is a free and open sourceincremental, journaling command-line archiver for Windows, Linux and Mac OS/X.Incremental means that when you back up your hard drive, forexample: zpaq add e:\backup.zpaq c:\*then only those files whose last-modified date or size has changed sincethe previousbackup are added. For 100 GB of files, this typically takes about a minute, vs.an hour to create the first version.Journaling means that the archive is append-only. When you addfiles or directories to the archive, both the old and new versions are saved.You can recover old versions by specifying the date or version number,for example: zpaq extract e:\backup.zpaq c:\Users\Bob -to tmp -until 2013-10-30will extract all the files and directories in c:\Users\Bob as of the lastbackup on or before Oct. 30, 2013 and put them in a directory named tmp.zpaq is faster and compresses better than most other popular archiversand backup programs,especially for realistic backups that have a lot of duplicate filesand a lot of already compressed files.Archive size vs. time tocompress and extract 10 GB (79,431 files) to an external USB harddrive at default and maximumsettings on a Dell Latitude E6510 laptop (Core i7 M620, 2+2hyperthreads, 2.66 GHz, 4 GB, Ubuntu Linux, Wine 1.6).Data from10 GB Benchmark (system 4).Feature comparison zpaq pcompress exdupe freearc obnam rar 7zip zipWindows W W W W W WLinux L L L L L L L LUpdate U U U U U U UIncremental I I I I IRollback R RDedupe D D D DEncryption E E E E E EGUI G G G GFree F F F F F F FOpen source O O O O O O OSpecification S S Downloadzpaq.exe for Windows.The latest version is zpaq v7.15,released Aug. 17, 2016. The downloadcontain source code (zpaq.cpp, libzpaq.cpp, libzpaq.h), Windows executables(32 or 64 bit, XP or later), documentation (zpaq.pod),and a Makefile for compiling in Linux, BSD, or Mac OS/X.You may need unzip.exe to unzip from theWindows command line.zpaq man page (HTML, latest version).The ZPAQ archive format is described by aspecification and reference decoder.A test caseexercising all of the specification features should decompress to theCalgary corpus.The compression algorithm is describedhere.The source code includes the libzpaq API providing compressionand decompression services for applications in C++.Developers may be interested in thezpaqd development tool and sample configuration filesfound on the utilities page.zpaq is written by Matt Mahoney and released to the public domain.It includes code from libdivsufsort 2.0 (C) Yuta Mori, 2003-2008, MIT license,public domain code for AES from libtomcrypt by Tom St Denis andpublic domain code for salsa20 by D. J. Bernstein.FeaturesA zpaq archive can contain at most 4 billion files and at most250 terabytes of data after deduplication and before compression.zpaq is for user-level backups. Do not use it to back up the operatingsystem or any software that requires a password to install.zpaq saves regular files and directories, last-modified dates (to thenearest second), and (optionally) Windows attributes or Linuxpermissions. It does not follow or save symbolic links or junctions.It unknowingly follows hard links. It does not save owner or group IDs,ACLs, extended attributes,the registry, or special file types like devices, sockets, or named pipes.Open standard specificationThe zpaq archive format is described by a precisespecification and reference decoder (above).The format is not encumbered by any patents or pending patentsin any country as far as I know. I have purposely published allpast versions (below) to establish prior art so that no patents can be filed.Backward and forward compatibilityAll versions of zpaq can read archives produced by older versionsback to version 1.00 (March 2009). To some extent, older versions canread archives produced by newer versions (forward compatibility) providedthey don't use any unsupported features. These are as follows:v1.00 (Mar. 2009). Level 1 format. Streaming archives with at leastone context model. Does not support deduplication or rollback.v5.00 (Aug. 2012). Level 2 format. Adds support for compressionwith pre/post processing with no context modeling (e.g. uncompressed or LZ77).v6.00 (Sept. 2012). Journaling format (dedupe and rollback).v6.44 (Jan. 2014). Encrypted archives.v6.47 (Jan. 2014). Multi-part archives. Older versions can read them if concatenated.Many intermediate versions include compression improvements. This doesnot break forward compatibility because the decompression codeis stored in the archive. The code is written in a sandboxed,virtual machine language called ZPAQL. On x86-32 and x86-64processors, the ZPAQL code is translated to machine code and executed,so it is as fast as compression algorithms written in compiledlanguages like C or C++. On other hardware, the ZPAQL code is interpreted,which takes about twice as long.For example, the following will create a streaming archive using BWTcompression that can be extracted by all versions back to v1.00, even thoughmost of these versions could not compress using BWT. zpaq add archive.zpaq files -method s4.3ci1RollbackAn archive is updated only by appending changes to it. You canroll back the archive to an earlier state by using the -until optionto specify the date and time or version number where to stop reading.When updating, -until will truncate the archive at thatpoint before appending. So if you backed up some files you didn't meanto, then you can truncate the last update and repeat: zpaq add backup c:\ -not c:\tmp -until -1Transacted updatesUpdates are committed by first appending a temporary header and thenupdating it when all of the compressed data and index changes are appended.If you interrupt zpaq (by typing Ctrl-C), then the partially appendeddata will be ignored and overwritten on the next update.DeduplicationWhen adding files,zpaq uses a rolling hash function to split files into fragmentswith an average size of 64 KB along content-dependent boundaries.Then it computes the SHA-1 hash of the fragment and compares it withsaved hashes from the current and previous versions.If it finds a match then the fragment is not stored.Deduplication requires 1 MB of memory per GB of deduplicatedbut uncompressed archive data to update, and 0.5 MB per GB tolist or extract.Incremental update and restoreFiles are added only if the date has changed since the last update.You can use the -force option to override, but in this case the filewill be deduplicated and not saved unless the contents have really changed.This is slower than comparing dates but faster than compressing it again.Extraction will not clobber existing files unless you give the-force option to allow overwrite. In this case, the file to be overwrittenis compared with the stored hashes and not decompressed unless the sizeor contents is different.Remote archive supportzpaq updates an archive by appending changes to it. To supportremote backups without having to move huge files,zpaq can put the appended changes into a separate,numbered file that you would copy or move to remote storage.You can concatenate the parts to form a complete archive, or simplyread them all at once by specifying a pattern in the archive namelike "part???.zpaq".zpaq will then search for part001.zpaq, part002.zpaq, etc. and regardthe concatenated sequence as a single archive.To make incremental backups with a local copy: zpaq add "arc???" files (copy arc001.zpaq) zpaq add "arc???" files (copy arc002.zpaq) zpaq list "arc???" (show contents) zpaq extract "arc???" (restore)To back up without keeping a local copy of the archive, you keepa small local index (arc000.zpaq) as a copy of the remote archive minusthe compressed file contents. zpaq maintains consistency between theindex and archive. zpaq add "arc???" files -index arc000.zpaq (move arc001.zpaq) zpaq add "arc???" files -index arc000.zpaq (move arc002.zpaq) zpaq list arc000 (show arc???.zpaq contents)EncryptionArchives can be encrypted using AES-256 in CTR mode.A password must be given every time an encrypted archive is used.Keys are strengthened with Scrypt(N=16384, r=8, p=1)(requiring 208M operations and 16 MB memory)to slow down brute force search for weakkeys. Encrypted archives are prefixed with a 32 byte random salt, whichalso provides an 8 byte IV for the first half of the 16 byte AES counter.If a remote archive has a local index, then both are encrypted with thesame key but different salts to generate independent keystreams.Encryption provides privacy but not authentication against tampering.All of the encryption code (AES, Scrypt, SHA-1, SHA-256)is public domain and tested against published test vectors.The AES code is derived from libtomcrypt 1.17.Multithreaded compressionzpaq has 5 compression levels. The default, -method 1, is the fastest.It is best for backups where you compress often and extract rarely.-method 2 compresses slower but decompresses as fast as -method 1.It is best for distributing files where you compress once and extractoften. Methods 3, 4, and 5 are slower with better compression.Fragments not removed by deduplication are packed into blocksfor compression. Files are sorted by filename extension and then bydecreasing size in order to group similar files together.The block size is 16 MB for method 1 and 64 MB for higher methods.You can change the block size to trade compression for memory usage.Blocks are compressed or decompressed in parallel in separate threads.zpaq automatically detects the number of processor cores and uses all of themin the 64 bit version or at most 2 in the 32 bit version (which is limitedto 2 GB memory).You can use the -threads option to change the number of threads.Resident memory per thread required to compress or decompress isapproximately as follows. Virtual memory usage may be higher. Method Compress Decompress Algorithm ------ -------- ---------- --------- 1 128 MB 32 MB LZ77 2 450 MB 128 MB LZ77 3 450 MB 400 MB LZ77+CM or BWT 4 550 MB 550 MB LZ77+CM, BWT or CM 5 850 MB 850 MB CMMethod 1 uses LZ77, compressing by replacing duplicate strings withpointers to previous occurrences. Method 2 is the same but spendsmore time looking for better matches (using a suffix array instead ofa hash table). Method 3 uses either BWT (context sorting) orLZ77 for long matches and an order 1 context model and arithmeticcoding for literals depending on the file type. Method 4 either uses LZ77, BWTor a high order context model. Method 5 uses a complex, high order contextmixing model with over 20 bit prediction components.All methods except 5 test whether the data appears to be compressibleor already compressed (random). Uncompressible data is simply stored.An E8E9 filter is applied if x86 data (normally found in .exe and .dllfiles) is detected. The filter replaces x86 CALL and JMP relativeaddresses with absolute addresses to make the data more compressible.Data analysiszpaq has list options to make it easier to examine the contentsof archives containing millions of files. For example, the followingcompares external dir1 to internal dir2 and lists only differences.Files are compared quickly by size and last modified date, or thoroughlyby reading the file, computing its SHA-1 hashes and comparing withthe hashes stored in the archive. zpaq list backup dir1 -to dir2 -not = (compare dates) zpaq list backup dir1 -to dir2 -not = -force (compare contents)Other useful list options: -only *.exe List only files ending with .exe -not *.exe Don't list files matching a pattern. -summary 20 List the 20 largest files and identify duplicates. -all Show all file versions. -until 20 List contents as of the 20'th updateError detection and recoveryzpaq archives are designed to minimize data loss if damaged. Anarchive is divided into blocks that can be decompressed independently.Each block begins with a 13 byte tag that can be found by scanningif the previous block is damaged. Each block ends with the SHA-1 hashof the uncompressed data, which is verified to detect errors. Blockswith hash mismatches or other errors are ignored with a warningwithout killing zpaq.Each update contains 4 types of blocks.C - Update header: date, size of compressed data.D - Compressed data fragments, list of fragment sizes.H - List of fragment hashes and sizes, one per D block.I - Index updates: list of files updated or deleted. Each update includes the date, attributes, and list of fragments.C blocks are used to skip over D blocks to read the index quickly.They are not needed to extract.If a D or H block is lost then so are any files that point to it.If an I block is lost, then so areany files in it. I blocks are small (16 KB) to minimize damage.When extracting files, the D block is decompressed up to the lastused fragment and those fragments are hashed and compared to thestored hashes in the H block.The zpaq -test -all extract option will decompress internallyand verify all of the fragment hashes without writing the output files.Public Domain APIThe source download includes libzpaq,a public domain application programming interface (API) in C++ thatprovides streaming compression and decompression servicesto and from files, strings, or arrays using built-in and customcompression algorithms. To use the code, you include libzpaq.hin your program and link to libzpaq.cpp.The API documentation is in libzpaq.h. The precise semantics isdescribed in the ZPAQ specification.In the simplest case,the application provides an error handling function and derivedimplementations of two abstract classes, Reader and Writer,specifying the input and output byte streams. For example, to compressfrom stdin to stdout (assuming binary I/O as in Linux): #include "libzpaq.h" #include #include void libzpaq::error(const char* msg) // print message and exit fprintf(stderr, "Oops: %s\n", msg); exit(1); class In: public libzpaq::Reader public: int get() return getchar(); // returns byte 0..255 or -1 at EOF in; class Out: public libzpaq::Writer public: void put(int c) putchar(c); // writes 1 byte 0..255 out; int main() libzpaq::compress(&in, &out, "1"); // -method 1 To decompress: libzpaq::decompress(&in, &out);There are also functions for reading and writing block and segmentheaders and for passing specialized methods or ZPAQL code to the compressor,as documented in libzpaq.h.The ZPAQ utilities pagecontains sample compression algorithms written in ZPAQLand a tool zpaqd for running, testing, and debugging ZPAQL.HistoryAll versions of the software and documentation can be downloadedbelow. The major development steps were:Feb. 15, 2009: zpaq 0.01, First of 9 experimental, mutually incompatible versions.Mar. 12, 2009: zpaq 1.00. First level 1 standard conforming archiver using interpreted ZPAQL for forward and backward compatibility.Sept. 29, 2010: libzpaq 1.00. First version of API providing compression services to applications in C++.Nov. 5, 2010: libzpaq 2.01. If an external C++ compiler is available then zpaq will translate ZPAQL to C++ and recompile itself to improve speed.Jan. 26, 2011: pzpaq 0.01. First multi-threaded version (later renamed zp, then merged back into zpaq).Nov. 13, 2011: libzpaq/zpaq 4.00. First version with JIT-accelerated ZPAQL for x86/64, eliminating need for external C++ compiler.Feb. 1, 2012: libzpaq 5.00. Level 2 standard allowed high speed compression without a context model (pre/post processing only).Sept. 26, 2012: zpaq 6.00. Journaling format to support deduplication, fast indexing, update recovery, and storing multiple versions of files and directories.June 11, 2013: zpaq 6.27. Moved developer tools into zpaqd.Dec. 20, 2013: zpaq 6.43. Adds AES encryption.Nov. 22, 2014: zpaq 6.56. Supports remote multi-part archives with a local index.zpaq versions 7.00 and older are licensed under GPL v3.The SHA-1 code used in versions prior to libzpaq 1.00is derived fromRFC 3174, whichis copyright (C) 2001, The Internet Society. Please see thisdocument for the full license. 2ff7e9595c
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